Lorazepam (2 Mg)
Pregnancy:D Lactation:L4 Lab:NA Food:NA
Acute nausea and vomiting, acute panic attacks, all forms of epilepsy, anxiety, anxiety associated with obsessional states, anxiety associated with phobic states, convulsions, insomnia, myoclonus, pre-operative anxiety.
Ataxia, CNS depression, dysarthria, dizziness, headache, drowsiness, nausea, blurred vision, confusion.
Lorazepam is known to interact with other drugs like alcohol, clarithromycin, lofepramine (HCl), loxapine, pemoline, pyrimethamine, silymarin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.