Escitalopram (25 Gm)
INDICATORS

Pregnancy:C Lactation:L4 Lab:NA Food:NA
TYPICAL USAGE

Treatment of major depressive disorder. Obsessive compulsive disorder. Panic disorder.

SIDE EFFECTS

Nausea, diarrhoea, increased sweating, insomnia.

DRUG INTERACTION

Increased risk of bleeding when used with aspirin, NSAIDs or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine).

MECHANISM OF ACTION

Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal re-uptake.